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As more and more people started using propolis, the number of cases reported with regard to it's side effect increases.


Periodontitis Treatment with Brazilian Propolis

Four patients, a 36 year old male and 3 females (42, 46, 51 years) with dental calculus, gingivitis, oedema, bleeding, gingival recession, pocket depths, attachment loss, suppuration, tooth mobility and alveolar bone loss were treated using Brazilian propolis gel treatment .

At the same time, dental brushing and mouth washing with propolis solution daily was also carried out through during the treatment of 5 weeks.

The results shown a regression of 95% gingivitis and suppuration in all the teeth irrigated with Brazilian propolis, as well as a pocket depths reduction in all unsubmitted and submitted teeth.

The results suggested that 10% Brazilian Propolis gel could be used as an alternative therapeutic method for the treatment of chronic teeth problems. However, further research with greater number of test subjects are needed before propolis can be established as an alternative approach for peridontal infectious conditions.

Researchers: Renata Cairo do Amaral, Rafael Tomaz Gomes, Wellington Márcio Santos Rocha, Sheila Lemos Rago Abreu, Vagner Rodrigues Santos.

Laboratory of Microbiology and Biomaterials, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

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Susceptibility of Oral Pathogenic Bacteria and Fungi to Brazilian Green Propolis Extract

The aim of this study was to investigate the antimicrobial activity of ethanolic extract and fractions of Brazilian green propolis (BGP) collected by bees from Baccharis dracunculifolia against 16 oral pathogenic microorganisms.

BGP was examinated by Reversed-Phase High-Performance Liquid
Chromatography (RPHPLC) and its absorption spectra was assessed using UV-Spectrophotometer.


Identification of flavonoids and other chemical constituents were carried out using authentic standards. Antimicrobial activity was evaluated by agar diffusion and dilution method.

The results indicate that all microorganisms tested were susceptible to BGP. None of the essayed fractions (Coumaric acid, Kaempferol, Pinobanskin-3-acetate, Chrysin, Galangin, Kaempferide, and Artepillin C) was more active than the extract, suggesting a synergistic effect of propolis constituents for the antimicrobial activity.

Researchers: Alfredo Mauricio Batista de Paula , Rafael Tomaz Gomes , Warner Kwasnicka Santiago , Ricardo Souza Dias , Maria Esperanza Cortés , Vagner Rodrigues Santos .

Laboratory of Microbiology and Biomaterials, Dentistry School, Universidade Federal de Minas Gerais; Food Microbiology Laboratory - Fundação Ezequiel Dias (FUNED) - Belo Horizonte, Brazil

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